Structural genomics of the severe acute respiratory syndrome coronavirus : Nuclear magnetic resonance structure of the protein nsP7
Identifieur interne : 004D58 ( Main/Exploration ); précédent : 004D57; suivant : 004D59Structural genomics of the severe acute respiratory syndrome coronavirus : Nuclear magnetic resonance structure of the protein nsP7
Auteurs : Wolfgang Peti [États-Unis] ; Margaret A. Johnson [États-Unis] ; Torsten Herrmann [États-Unis] ; Benjamin W. Neuman [États-Unis] ; Michael J. Buchmeier [États-Unis] ; Mike Nelson [États-Unis] ; Jeremiah Joseph [États-Unis] ; Rebecca Page [États-Unis] ; Raymond C. Stevens [États-Unis] ; Peter Kuhn [États-Unis] ; Kurt Wüthrich [États-Unis]Source :
- Journal of virology [ 0022-538X ] ; 2005.
Descripteurs français
- KwdFr :
- Alignement de séquences, Données de séquences moléculaires, Modèles moléculaires, Polyprotéines (), Protéines virales (), Protéines virales (génétique), Protéines virales (physiologie), RNA replicase (), RNA replicase (génétique), Résonance magnétique nucléaire biomoléculaire, Structure secondaire des protéines, Structure tertiaire des protéines (génétique), Séquence d'acides aminés, Virus du SRAS (), Virus à ARN (métabolisme).
- MESH :
- génétique : Protéines virales, RNA replicase, Structure tertiaire des protéines.
- métabolisme : Virus à ARN.
- physiologie : Protéines virales.
- Pascal (Inist)
- Alignement de séquences, Coronavirus, Données de séquences moléculaires, Génomique, Modèles moléculaires, Polyprotéines, Protéine, Microbiologie, Protéines virales, RNA replicase, Résonance magnétique nucléaire biomoléculaire, Structure secondaire des protéines, Séquence d'acides aminés, Virologie, Syndrome respiratoire aigu sévère, Virus du SRAS.
English descriptors
- KwdEn :
- Amino Acid Sequence, Coronavirus, Genomics, Microbiology, Models, Molecular, Molecular Sequence Data, Nuclear Magnetic Resonance, Biomolecular, Polyproteins (chemistry), Protein, Protein Structure, Secondary, Protein Structure, Tertiary (genetics), RNA Replicase (chemistry), RNA Replicase (genetics), RNA Viruses (metabolism), SARS Virus (chemistry), Sequence Alignment, Severe acute respiratory syndrome, Viral Proteins (chemistry), Viral Proteins (genetics), Viral Proteins (physiology), Virology.
- MESH :
- chemical , chemistry : Polyproteins, RNA Replicase, Viral Proteins.
- chemistry : SARS Virus.
- genetics : Protein Structure, Tertiary, RNA Replicase, Viral Proteins.
- metabolism : RNA Viruses.
- chemical , physiology : Viral Proteins.
- Amino Acid Sequence, Models, Molecular, Molecular Sequence Data, Nuclear Magnetic Resonance, Biomolecular, Protein Structure, Secondary, Sequence Alignment.
Abstract
Here, we report the three-dimensional structure of severe acute respiratory syndrome coronavirus (SARS-CoV) nsP7, a component of the SARS-CoV replicase polyprotein. The coronavirus replicase carries out regulatory tasks involved in the maintenance, transcription, and replication of the coronavirus genome. nsP7 was found to assume a compact architecture in solution, which is comprised primarily of helical secondary structures. Three helices (a2 to a4) form a flat up-down-up antiparallel α-helix sheet. The N-terminal segment of residues 1 to 22, containing two turns of α-helix and one turn of 310-helix, is packed across the surface of a2 and a3 in the helix sheet, with the α-helical region oriented at a 60° angle relative to a2 and α3. The surface charge distribution is pronouncedly asymmetrical, with the flat surface of the helical sheet showing a large negatively charged region adjacent to a large hydrophobic patch and the opposite side containing a positively charged groove that extends along the helix al. Each of these three areas is thus implicated as a potential site for protein-protein interactions.
Url:
Affiliations:
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Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Structural genomics of the severe acute respiratory syndrome coronavirus : Nuclear magnetic resonance structure of the protein nsP7</title>
<author><name sortKey="Peti, Wolfgang" sort="Peti, Wolfgang" uniqKey="Peti W" first="Wolfgang" last="Peti">Wolfgang Peti</name>
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<country>États-Unis</country>
<wicri:noRegion>La Jolla, California 92037</wicri:noRegion>
</affiliation>
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<author><name sortKey="Johnson, Margaret A" sort="Johnson, Margaret A" uniqKey="Johnson M" first="Margaret A." last="Johnson">Margaret A. Johnson</name>
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</author>
<author><name sortKey="Herrmann, Torsten" sort="Herrmann, Torsten" uniqKey="Herrmann T" first="Torsten" last="Herrmann">Torsten Herrmann</name>
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</author>
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</author>
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<author><name sortKey="Kuhn, Peter" sort="Kuhn, Peter" uniqKey="Kuhn P" first="Peter" last="Kuhn">Peter Kuhn</name>
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</analytic>
<series><title level="j" type="main">Journal of virology</title>
<title level="j" type="abbreviated">J. virol.</title>
<idno type="ISSN">0022-538X</idno>
<imprint><date when="2005">2005</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Journal of virology</title>
<title level="j" type="abbreviated">J. virol.</title>
<idno type="ISSN">0022-538X</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Coronavirus</term>
<term>Genomics</term>
<term>Microbiology</term>
<term>Models, Molecular</term>
<term>Molecular Sequence Data</term>
<term>Nuclear Magnetic Resonance, Biomolecular</term>
<term>Polyproteins (chemistry)</term>
<term>Protein</term>
<term>Protein Structure, Secondary</term>
<term>Protein Structure, Tertiary (genetics)</term>
<term>RNA Replicase (chemistry)</term>
<term>RNA Replicase (genetics)</term>
<term>RNA Viruses (metabolism)</term>
<term>SARS Virus (chemistry)</term>
<term>Sequence Alignment</term>
<term>Severe acute respiratory syndrome</term>
<term>Viral Proteins (chemistry)</term>
<term>Viral Proteins (genetics)</term>
<term>Viral Proteins (physiology)</term>
<term>Virology</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Alignement de séquences</term>
<term>Données de séquences moléculaires</term>
<term>Modèles moléculaires</term>
<term>Polyprotéines ()</term>
<term>Protéines virales ()</term>
<term>Protéines virales (génétique)</term>
<term>Protéines virales (physiologie)</term>
<term>RNA replicase ()</term>
<term>RNA replicase (génétique)</term>
<term>Résonance magnétique nucléaire biomoléculaire</term>
<term>Structure secondaire des protéines</term>
<term>Structure tertiaire des protéines (génétique)</term>
<term>Séquence d'acides aminés</term>
<term>Virus du SRAS ()</term>
<term>Virus à ARN (métabolisme)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Polyproteins</term>
<term>RNA Replicase</term>
<term>Viral Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Protein Structure, Tertiary</term>
<term>RNA Replicase</term>
<term>Viral Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Protéines virales</term>
<term>RNA replicase</term>
<term>Structure tertiaire des protéines</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>RNA Viruses</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Virus à ARN</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Protéines virales</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Viral Proteins</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Models, Molecular</term>
<term>Molecular Sequence Data</term>
<term>Nuclear Magnetic Resonance, Biomolecular</term>
<term>Protein Structure, Secondary</term>
<term>Sequence Alignment</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Alignement de séquences</term>
<term>Coronavirus</term>
<term>Données de séquences moléculaires</term>
<term>Génomique</term>
<term>Modèles moléculaires</term>
<term>Polyprotéines</term>
<term>Protéine</term>
<term>Microbiologie</term>
<term>Protéines virales</term>
<term>RNA replicase</term>
<term>Résonance magnétique nucléaire biomoléculaire</term>
<term>Structure secondaire des protéines</term>
<term>Séquence d'acides aminés</term>
<term>Virologie</term>
<term>Syndrome respiratoire aigu sévère</term>
<term>Virus du SRAS</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Here, we report the three-dimensional structure of severe acute respiratory syndrome coronavirus (SARS-CoV) nsP7, a component of the SARS-CoV replicase polyprotein. The coronavirus replicase carries out regulatory tasks involved in the maintenance, transcription, and replication of the coronavirus genome. nsP7 was found to assume a compact architecture in solution, which is comprised primarily of helical secondary structures. Three helices (a2 to a4) form a flat up-down-up antiparallel α-helix sheet. The N-terminal segment of residues 1 to 22, containing two turns of α-helix and one turn of 3<sub>10</sub>
-helix, is packed across the surface of a2 and a3 in the helix sheet, with the α-helical region oriented at a 60° angle relative to a2 and α3. The surface charge distribution is pronouncedly asymmetrical, with the flat surface of the helical sheet showing a large negatively charged region adjacent to a large hydrophobic patch and the opposite side containing a positively charged groove that extends along the helix al. Each of these three areas is thus implicated as a potential site for protein-protein interactions.</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
</list>
<tree><country name="États-Unis"><noRegion><name sortKey="Peti, Wolfgang" sort="Peti, Wolfgang" uniqKey="Peti W" first="Wolfgang" last="Peti">Wolfgang Peti</name>
</noRegion>
<name sortKey="Buchmeier, Michael J" sort="Buchmeier, Michael J" uniqKey="Buchmeier M" first="Michael J." last="Buchmeier">Michael J. Buchmeier</name>
<name sortKey="Buchmeier, Michael J" sort="Buchmeier, Michael J" uniqKey="Buchmeier M" first="Michael J." last="Buchmeier">Michael J. Buchmeier</name>
<name sortKey="Herrmann, Torsten" sort="Herrmann, Torsten" uniqKey="Herrmann T" first="Torsten" last="Herrmann">Torsten Herrmann</name>
<name sortKey="Johnson, Margaret A" sort="Johnson, Margaret A" uniqKey="Johnson M" first="Margaret A." last="Johnson">Margaret A. Johnson</name>
<name sortKey="Johnson, Margaret A" sort="Johnson, Margaret A" uniqKey="Johnson M" first="Margaret A." last="Johnson">Margaret A. Johnson</name>
<name sortKey="Joseph, Jeremiah" sort="Joseph, Jeremiah" uniqKey="Joseph J" first="Jeremiah" last="Joseph">Jeremiah Joseph</name>
<name sortKey="Joseph, Jeremiah" sort="Joseph, Jeremiah" uniqKey="Joseph J" first="Jeremiah" last="Joseph">Jeremiah Joseph</name>
<name sortKey="Kuhn, Peter" sort="Kuhn, Peter" uniqKey="Kuhn P" first="Peter" last="Kuhn">Peter Kuhn</name>
<name sortKey="Kuhn, Peter" sort="Kuhn, Peter" uniqKey="Kuhn P" first="Peter" last="Kuhn">Peter Kuhn</name>
<name sortKey="Kuhn, Peter" sort="Kuhn, Peter" uniqKey="Kuhn P" first="Peter" last="Kuhn">Peter Kuhn</name>
<name sortKey="Nelson, Mike" sort="Nelson, Mike" uniqKey="Nelson M" first="Mike" last="Nelson">Mike Nelson</name>
<name sortKey="Nelson, Mike" sort="Nelson, Mike" uniqKey="Nelson M" first="Mike" last="Nelson">Mike Nelson</name>
<name sortKey="Neuman, Benjamin W" sort="Neuman, Benjamin W" uniqKey="Neuman B" first="Benjamin W." last="Neuman">Benjamin W. Neuman</name>
<name sortKey="Neuman, Benjamin W" sort="Neuman, Benjamin W" uniqKey="Neuman B" first="Benjamin W." last="Neuman">Benjamin W. Neuman</name>
<name sortKey="Page, Rebecca" sort="Page, Rebecca" uniqKey="Page R" first="Rebecca" last="Page">Rebecca Page</name>
<name sortKey="Page, Rebecca" sort="Page, Rebecca" uniqKey="Page R" first="Rebecca" last="Page">Rebecca Page</name>
<name sortKey="Peti, Wolfgang" sort="Peti, Wolfgang" uniqKey="Peti W" first="Wolfgang" last="Peti">Wolfgang Peti</name>
<name sortKey="Stevens, Raymond C" sort="Stevens, Raymond C" uniqKey="Stevens R" first="Raymond C." last="Stevens">Raymond C. Stevens</name>
<name sortKey="Stevens, Raymond C" sort="Stevens, Raymond C" uniqKey="Stevens R" first="Raymond C." last="Stevens">Raymond C. Stevens</name>
<name sortKey="Stevens, Raymond C" sort="Stevens, Raymond C" uniqKey="Stevens R" first="Raymond C." last="Stevens">Raymond C. Stevens</name>
<name sortKey="Wuthrich, Kurt" sort="Wuthrich, Kurt" uniqKey="Wuthrich K" first="Kurt" last="Wüthrich">Kurt Wüthrich</name>
<name sortKey="Wuthrich, Kurt" sort="Wuthrich, Kurt" uniqKey="Wuthrich K" first="Kurt" last="Wüthrich">Kurt Wüthrich</name>
<name sortKey="Wuthrich, Kurt" sort="Wuthrich, Kurt" uniqKey="Wuthrich K" first="Kurt" last="Wüthrich">Kurt Wüthrich</name>
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